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In this study, we show that VDR is required for the morphogenetic process that controls hair cycle progression and cell division within the hair follicle (HF). We identify Vdr as a key regulator of catagen, by demonstrating that the Vdr cKO phenotype is due to diminished apoptosis of epithelial strands of epithelial cells that have been killed in the HF during the catagen stage. This delay in the entry of the HF to anagen can cause alopecia. the HF is transformed into a dermal cyst composed of epidermal cells.
To study the role of VDR in the regulation of apoptosis during catagen, we conducted a comprehensive screen for putative VDR targets using functional annotation enrichment analysis. Comparing to control CO fibroblasts, we identified 268 genes that were upregulated by the unliganded VDR and decreased by 1,25D-dependent activation. The majority of these genes are upregulated by WT fibroblasts.
The most important thing to consider with any VDR is the level of security it offers to all users. Select a VDR that offers customized permission controls to safeguard your data and two-step authentication to prevent prevention of password theft audit logs, secure connection to your browser as well as monitoring 24/7.